| African Wildlife Fndn. | 1167 | EarthShare NC - Federation | Protects imperiled species-- lions, mountain gorillas, rhinos, elephants,-- through habitat conservation, wildlife protection, leadership training, and wildlife-friendly community-beneficial business development for more than 50 years. |
| Alley Cat Allies | 2919 | America's Best Charities - Federation | Every 15 seconds a healthy cat is killed in a shelter. Our programs help shelters save more cats and kittens, but we need your help. |
| Alley Cat Rescue | 5077 | America's Best Charities - Federation | Stray, abandoned and feral cats are neglected. Healthy cats in shelters are killed. Your contribution helps us end feline overpopulation and suffering. |
| America’s Best Charities | 1900 | America's Best Charities - Federation | Feeding the hungry. Sheltering the homeless. Protecting the children. And healing the sick. America's finest independent charities. Working with you to share- the American way. |
| American Kennel Club Canine Health Fndn. | 2922 | America's Best Charities - Federation | Help dogs live longer, healthier lives by fighting canine diseases like cancer, epilepsy, eye and heart disease. Our work furthers human treatments and cures, too. |
| Animal League America | 5091 | America's Best Charities - Federation | Support the largest no-kill animal rescue and adoption organization in the world. We save the lives of pets through rescue, adoption, spay/neuter, education initiatives. |
| Animal Legal Defense Fund | 1927 | America's Best Charities - Federation | Animals need love - and lawyers! Unimaginable acts of cruelty must end. In courtrooms across America, ALDF is winning the case against cruelty! |
| Animal Protection Society, Durham | 4060 | Independent Agency | We are a leader in building lifelong bonds between people and animals through education, community outreach and providing care for animals in need. |
| Animal Protection Society, Orange Co. | 3729 | Independent Agency | Paws4ever is a guaranteed adoption animal shelter and sanctuary dedicated to improving the lives of cats and dogs through adoption, training, and education. |
| AnimalKind | 1529 | Independent Agency | To provide financial assistance to low-income residents for pet spay/neuter through THE $20 FIX Program & the SpayNC information/referral service to all NC residents by phone and online assistance. |
| ASPCA – Society for the Prevention of Cruelty to Animals | 1987 | America's Best Charities - Federation | Staged dog fights to the death. Puppy factories with overcrowded and unsanitary breeding pens. Kittens tortured for amusement. Help stop these acts of animal cruelty. |
| Assistant Dog Institute | 5094 | America's Best Charities - Federation | Our Dogs Helping Veterans program helps heal returning service members by providing loving dog helpmates at no cost to those with physical and psychological disabilities. |
| Best Friends Animal Society | 1692 | America's Charities - Federation | For 35+ years, we've run the nation’s largest no-kill sanctuary for companion animals and built effective programs reducing the number of animals entering shelters. |
| Big Cat Rescue Corp | 5020 | America's Best Charities - Federation | Tigers confined to circus wagons. Lions bred for photos then to be shot in cages. Lynx farmed for their fur. Help us save big cats. |
| Blind Cat Rescue & Sanctuary | 3859 | Independent Agency | Blind Cat Rescue & Sanctuary provides a safe, loving and healthy permanent home for blind, FIV+ and feline leukemia-positive cats deemed unadoptable. |
| Born Free USA | 1145 | EarthShare NC - Federation | Works to end the suffering of wild animals in captivity, rescue individual animals in need, protect wildlife, including endangered species, and encourage compassionate conservation globally. |
| Canine Assistants | 1989 | America's Best Charities - Federation | Teaching great dogs for special people. Invest in freedom by providing service dogs to children and adults with disabilities. Thank you! |
| Canines for Service | 3602 | Independent Agency | Canines for Service empowers Veterans from all conflicts with service-connected disabilities, by providing highly trained service dogs to at no cost or promotional requirement. |
| Carolina Animal Rescue & Adoption | 4103 | Independent Agency | To promote responsible pet ownership through humane education, and to provide shelter and care to domestic companion animals |
| Carolina Raptor Center | 1105 | EarthShare NC - Federation | Provides environmental education, raptor rehabilitation and raptor medical training worldwide. Visitors to the center enjoy one of the country's largest displays of raptors. |
| Carolina Tiger Rescue | 1104 | EarthShare NC - Federation | Provides rescue and sanctuary for wild cats; conservation education through tours, community outreach and summer camp; and opportunities for volunteering, internships, and community service. |
| Cats’ Cradle, The | 4133 | Independent Agency | Feline rescue organization dedicated to rescuing and rehabilitating abused or abandoned cats and adopting them into loving forever homes, or providing lifetime care. |
| Chatham Animal Rescue and Education | 3604 | Independent Agency | Promote responsible pet ownership by educating the community, providing targeted spay/neuter programs, and fostering homeless dogs and cats. |
| Days End Farm Horse Rescue | 5055 | America's Best Charities - Federation | Starvation, parasite infestation, deformed hoofs. Caring for abused and neglected horses. Dedicated to ensuring quality care and treatment of horses through intervention, education and outreach. |
| Defenders of Wildlife | 1140 | EarthShare NC - Federation | Founded in 1947, Defenders of Wildlife is a major conservation organization focused solely on wildlife and habitat conservation and the safeguarding of biodiversity. |